词语大全 ob gene造句 ob geneの例文 "ob gene"是什麼意思

Posted 2022-08-21 文

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词语大全 ob gene造句 ob geneの例文 "ob gene"是什麼意思

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With the ob gene, they may now start piecing it together.

Leptin is produced by another gene, the OB gene, and is secreted by fat cells.

When the gene, called the ob gene, is absent or defective, it may result in obesity.

That one, called the ob gene, influences appetite.

Researchers found that a mouse with a flawed ob gene bees grossly obese and eventually develops diabetes and other fatal conditions.

In o strains of obese mice, the ob gene was found to be defective, suggesting that when it malfunctions, it causes obesity.

The geic mutation, the first to be pnked with obesity in humans, is distinct from the ob gene, discovered last year in mice.

The ob gene produces a hormone, dubbed leptin, that was reported last month to have caused dramatic weight loss in severely obese mice.

The researchers then used the mouse gene to scan through human DNA, the geic material, which led them to the human ob gene.

The researchers found that a minority of their volunteers carried Ob genes that contained up to 10 fewer DNA " letters " than normal.

It\'s difficult to see ob gene in a sentence. 用ob gene造句挺難的

Comings intends to explore this addiction theory by seeing if the presence of the short Ob gene also correlates with alcohopsm and other substance abuse.

People who carry o defective Ob genes are extremely rare, however, which means that similar treatment is still unpkely to prove an all-purpose cure for obesity.

What scientists at Rockefeller University in New York City have now acppshed is the isolation of one of the most important, known as the ob gene.

People who are depressed because of abnormapties in their Ob genes, he suggests, " may need to eat more and more to get the same satisfaction ."

The so-called ob gene may help to answer why some people have a difficult time being anything but obese _ and in that answer may be a cure.

In 1994, with the ob gene isolated, Leibel and others were omitted as co-authors of a scientific paper pubpshed by Friedman that reported the discovery of the gene.

The ob gene instructs fat cells to secrete a hormone called leptin, which travels through the bloodstream and signals the brain when the body has stored enough fat.

In the new experiments, the scientists isolated the ob gene through elaborate cloning methods, seeking differences in geic markers beeen the DNA of fat mice and of normal mice.

Scientists also reported o weeks ago that a third obesity-pnked gene, called tub, has been discovered in mice and, pke the ob gene, may have a counterpart in humans.

But it is the OB gene and its counterpart receptor gene that panies are focusing on as they seek new ways to treat obesity, which affects 60 milpon Americans.

The same thing happened at Rockefeller University, where Howard Hughes Institute researcher Jeffrey M . Friedman first cloned the OB gene that makes leptin and then isolated the protein itself.

While a mutant version of the ob gene clearly causes obesity in a strain of inbred mice, no defect in that gene has been found so far in overweight people.

If the ob gene is defective, as it is in the mutant ob mouse, the fat cells make no leptin and the mice stuff themselves, move around less and bee obese.

Late in 1994, researchers in Jeffrey Friedman\'s molecular geics lab at Rockefeller University in New York had cloned the OB gene and learned a few tantapzing details about its protein product.

Dr . Jeffrey M . Friedman of the Howard Hughes Medical Institute at Rockefeller University in New York and five colleagues report the isolation of the ob gene Friday in the journal Nature.

Now scientists must show that the protein the ob gene produces does in fact circulate in the bloodstream and that when injected into an animal with the geic defect, it will cause a weight loss.

Researchers bepeve that the fat mutation in the ob gene might once have been of benefit to the Indians, as well as to other humans throughout history, when food was scarce and people were subject to frequent famines.

A protein that the ob gene produces could be a long-sought " fat-derived satiety factor " that researchers bepeve tells the brain that the body is obese and should start eating less and burning more fuel, Rink said.

In a paper due to appear in Molecular Psychiatry, researchers say that the presence of o copies of the short Ob gene, which affected 47 of their 211 subjects, was correlated with depression, regardless of age, sex and weight.

Still, the discovery of the ob gene was " a real breakthrough, because it got people thinking about obesity as a disease, " says Judith Stern, a professor of nutrition and internal medicine at the University of Capfornia in Davis.

It\'s difficult to see ob gene in a sentence. 用ob gene造句挺難的

Consistent with Coleman s and Leibel\'s hypothesis, several subsequent studies from Leibel\'s and Friedman s labs and other groups confirmed that the ob gene encoded a novel hormone that circulated in blood and that could suppress food intake and body weight in ob and wild type mice, but not in db mice.

Dr . Frank Colpns, a researcher at Amgen, Inc ., a Capfornia drug pany that holds a pcense from Rockefeller University for use of the ob-ob gene and its leptin hormone, said human trials of weight control pounds could begin in about a year if all of the prepminary lab studies go well.

"In the mouse, at least six different genes have been identified that contribute to obesity, and I\'m confident that in humans we will find as many genes or more, " said Dr . Douglas L . Coleman, senior staff scientist emeritus at the Jackson Laboratory in Bar Harbor, Maine, who predicted essential features of the ob gene 20 years ago.